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Anti-SHP1 PTPN6 Rabbit Monoclonal Antibody

Boster Bio Anti-SHP1 PTPN6 Rabbit Monoclonal Antibody catalog # M00938. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Tyrosine-protein phosphatase non-receptor type 6;3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1; PTPN6; HCP, PTP1C

Gene Name

PTPN6

Gene ID

5777

UniProt

P29350

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human SHP1

Clonality

Monoclonal

Clone

Clone: CGH-16

Tissue Specificity

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Applications

WB, IHC

Field of Research

Cancer, Cell Biology, Cell Cycle, Developmental Biology, G Protein Signaling, Kinases/Phosphatases, Organogenesis, Signal Transduction, Signaling Pathway

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

67561 MW

Observed Molecular Weight

78 kDa

Gene Name Synonym

Tyrosine-protein phosphatase non-receptor type 6

Subcellular Location

Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity) . Shuttles between the cytoplasm and nucleus via its association with PDPK1. .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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