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Anti-CD45 PTPRC Rabbit Monoclonal Antibody

Boster Bio Anti-CD45 PTPRC Rabbit Monoclonal Antibody catalog # M00555-1. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Synonyms

Receptor-type tyrosine-protein phosphatase C;3.1.3.48; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45

Gene Name

PTPRC

Gene ID

5788

UniProt

P08575

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human CD45

Clonality

Monoclonal

Clone

Clone: CBI-16

Tissue Specificity

Ubiquitous.

Applications

WB, IHC, ICC, IF, Flow Cytometry

Field of Research

Adapters, Adaptive Immunity, B Cells, Cell Type Markers, Immunology, Protein Phosphorylation, Signal Transduction, T Cells, Transmembrane, Tyrosine Phosphatases

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

147254 MW

Observed Molecular Weight

17 kDa

Gene Name Synonym

Receptor-type tyrosine-protein phosphatase C

Subcellular Location

Membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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