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Anti-A2M/Alpha 2 Macroglobulin Rabbit Monoclonal Antibody

Boster Bio Anti-A2M/Alpha 2 Macroglobulin Rabbit Monoclonal Antibody catalog # M01498. Tested in WB, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M; CPAMD5; FWP007

Gene Name

A2M

Gene ID

2

UniProt

P01023

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human A2M

Clonality

Monoclonal

Clone

Clone: ABAO-1

Tissue Specificity

Secreted in plasma. .

Applications

WB, IHC

Field of Research

Cell Biology, Complement, Immunology, Innate Immunity, Protease Inhibitors, Proteolysis/Ubiquitin

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced) . Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

163291 MW

Observed Molecular Weight

60 kDa

Gene Name Synonym

Alpha-2-macroglobulin

Subcellular Location

Secreted .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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