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Anti-AhR Rabbit Monoclonal Antibody

Boster Bio Anti-AhR Rabbit Monoclonal Antibody catalog # M00225. Tested in WB, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Synonyms

Aryl hydrocarbon receptor; Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76; AHR; BHLHE76

Gene Name

AHR

Gene ID

196

UniProt

P35869

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human AhR

Clonality

Monoclonal

Clone

Clone: AOHI-1

Tissue Specificity

Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. .

Applications

WB, ICC, IF

Field of Research

Epigenetics and Nuclear Signaling, NFKB Pathway, Nuclear Signaling Pathways

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) . Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

96147 MW

Observed Molecular Weight

96,105 kDa

Gene Name Synonym

Aryl hydrocarbon receptor

Subcellular Location

Cytoplasm. Nucleus. Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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