Anti-Phospho-Rac1/Cdc42 (Ser71) Rabbit Monoclonal Antibody
Boster Bio Anti-Phospho-Rac1/Cdc42 (Ser71) Rabbit Monoclonal Antibody catalog # P00119. Tested in WB application. This antibody reacts with Human.
Product Specifications
Phospho Site
Ser71
Synonyms
Cell division control protein 42 homolog; G25K GTP-binding protein; CDC42
Gene Name
CDC42
Gene ID
998
UniProt
P60953/P63000
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human Phospho-Rac1/Cdc42 (Ser71)
Clonality
Monoclonal
Clone
Clone: IBB-3
Tissue Specificity
Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level) . .
Applications
WB
Field of Research
Cancer, Cell Biology, Cell Cycle, Cell Division, Cytokinesis, Epigenetics and Nuclear Signaling, G Protein Signaling, Kinases/Phosphatases, Protein Trafficking, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins, Vesicle Transport
Purification
Affinity-chromatography
Concentration
0.5mg/ml
Form
Liquid
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
21259 MW
Observed Molecular Weight
70, 75 kDa
Gene Name Synonym
Cell division control protein 42 homolog
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.
Isotype
Rabbit IgG
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
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