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Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody

Boster Bio Anti-Phospho-CrkII (Tyr221) Rabbit Monoclonal Antibody catalog # P02533. Tested in WB, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Phospho Site

Tyr221

Synonyms

Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK

Gene Name

CRK

Gene ID

1398

UniProt

P46108

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Phospho-CrkII (Tyr221)

Clonality

Monoclonal

Clone

Clone: FDE-3

Tissue Specificity

Expressed in brain, and to a lesser extent in lung, kidney and testis.

Applications

WB, ICC, IF

Field of Research

Adapters, Cancer, Cytoplasmic, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

33831 MW

Observed Molecular Weight

85 kDa

Gene Name Synonym

Adapter molecule crk

Subcellular Location

Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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