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Anti-Phospho-eIF4E (S209) Rabbit Monoclonal Antibody

Boster Bio Anti-Phospho-eIF4E (S209) Rabbit Monoclonal Antibody catalog # P00135. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Phospho Site

S209

Synonyms

Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; EIF4E; EIF4EL1, EIF4F

Gene Name

EIF4E

Gene ID

1977

UniProt

P06730

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Phospho-eIF4E (S209)

Clonality

Monoclonal

Clone

Clone: DBD-5

Tissue Specificity

Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level) . .

Applications

WB, IHC, ICC, IF, IP

Field of Research

DNA/RNA, Epigenetics and Nuclear Signaling, RNA Processing, Translation

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=P00135

Product MSDS

https://www.bosterbio.com/msds?sku=P00135

Calculated Molecular Weight

25097 MW

Observed Molecular Weight

70, 75 kDa

Gene Name Synonym

Eukaryotic translation initiation factor 4E

Subcellular Location

Cytoplasm, P-body . Cytoplasm .

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

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