Anti-Galectin 3/LGALS3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Galectin-3 (GAL3), also known as LGALS3, MAC2 or GALBP, is a member of the lectin family, of which 14 mammalian galectins have been identified. Galectin-3 is encoded by a single gene, it located on chromosome 14, locus q21– q22. It is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space. Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and Ventricular remodeling. Galectin-3 is expressed in various tissues and organs, but is significantly absent in normal hepatocytes.
Synonyms
Galectin-3; Gal-3;35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen; LGALS3; MAC2
Gene Name
LGALS3
Gene ID
3958
UniProt
P17931
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human Galectin 3 recombinant protein (Position: K139-I250) . Human Galectin 3 shares 88% and 84% amino acid (aa) sequences identity with mouse and rat Galectin 3, respectively.
Clonality
Polyclonal
Tissue Specificity
A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. .
Applications
Flow Cytometry
Field of Research
Cancer, Cell Cycle, Cell Division, Oncoproteins, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity) . In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. .
References & Citations
1. Dumic J, Dabelic S, Flögel M. (2006) . Galectin-3: an open-ended story.. BBA General Subjects 1760 (4) : 616–635. 2. Liu F, Patterson RJ, Wang JL. (2002) . Intracellular function of galectins.. BBA General Subjects 1572 (2-3) : 263–273. 3. Cooper D. (2002) . Galectinomics: finding themes in complexity.. BBA General Subjects 1572 (2-3) : 209–231. 4. Raimond J, Zimonjic DB, Mignon C, et al. (1997) . Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q21—22.. Mamm. Genome 8 (9) : 706–707.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
26152 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Galectin-3
Subcellular Location
Cytoplasm. Nucleus. Secreted. Secreted by a non-classical secretory pathway and associates with the cell surface.
Sequence Similarities
Contains 1 galectin domain.
Protein Name
Galectin-3
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
More Discoveries
Explore Other Products
Browse additional items from our catalog
K3507206 1.0 µg DNA
0610011F06Rik sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
Sign In for Pricing
View Details 
MBS7160527 Inquire
Rabbit anti-Saccharomyces cerevisiae (strain 204508/S288c)(Baker's yeast) YPR003C Polyclonal Antibody
Sign In for Pricing
View Details 
LV670330 1.0 µg DNA
Rgsl2h Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
Sign In for Pricing
View Details