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Anti-CD34 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 KD.CD34 is expressed in humans in hematopoietic stem cells, vascular endothelium, and blasts from 30% of patients with acute myeloid and lymphocytic leukemia. The human CD34 gene spans 26 kb and has 8 exons, a structure quite similar to that of the murine gene. By Southern blot analysis of DNA from a panel of human x mouse somatic cell hybrids using a CD34 cDNA probe demonstrate that the gene for CD34 is located on human chromosome 1 in the 1q12----qter region. CD34 plays an important role in the formation of progenitor cells during both embryonic and adult hematopoiesis.

Synonyms

Hematopoietic progenitor cell antigen CD34; CD34; CD34

Gene Name

CD34

Gene ID

947

UniProt

P28906

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CD34 recombinant protein (Position: T151-L385) . Human CD34 shares 79% amino acid (aa) sequence identity with mouse CD34.

Clonality

Polyclonal

Tissue Specificity

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Applications

Flow Cytometry

Field of Research

Cardiogenesis, Cardiovascular, Cell Type Marker, Cell Type Markers, Developmental Biology, Hematopoietic Progenitors, Immunology, Lineage Markers, Lineage Specification, Mesenchymal Stem Cells, Neuron Marker, Neuroscience, Stem Cells, Surface Molecules, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or ly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

References & Citations

1. Satterthwaite, A. B., Burn, T. C., Le Beau, M. M., Tenen, D. G. Structure of the gene encoding CD34, a human hematopoietic stem cell antigen. Genomics 12: 788-794, 1992. 2. Tenen, D. G., Satterthwaite, A. B., Borson, R., Simmons, D., Eddy, R. L., Shows, T. B. Chromosome 1 localization of the gene for CD34, a surface antigen of human stem cells. Cytogenet. Cell Genet. 53: 55-57, 1990. 3. Cheng, J., Baumhueter, S., Cacalano, G., Carver-Moore, K., Thibodeaux, H., Thomas, R., Broxmeyer, H. E., Cooper, S., Hague, N., Moore, M., Lasky, L. A. Hematopoietic defects in mice lacking the sialomucin CD34. Blood 87: 479-490, 1996.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

40716 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Hematopoietic progenitor cell antigen CD34

Subcellular Location

Membrane; Single-pass type I membrane protein.

Sequence Similarities

Belongs to the CD34 family.

Protein Name

Hematopoietic progenitor cell antigen CD34

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

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