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Anti-CD20/MS4A1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

CD20, also known as MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. It is mapped to 11q12.2. This gene encodes a member of the membrane-spanning 4A gene family. The function of CD20 is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that CD20 acts as a calcium channel in the cell membrane. What’s more, this protein may be involved in the regulation of B-cell activation and proliferation.

Synonyms

B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20; MS4A1; CD20

Gene Name

MS4A1

Gene ID

931

UniProt

P11836

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CD20 recombinant protein (Position: M1-D261) . Human CD20 shares 75% amino acid (aa) sequence identity with mouse CD20.

Clonality

Polyclonal

Tissue Specificity

Expressed on B-cells.

Applications

Flow Cytometry

Field of Research

Adapters, Signal Transduction, Transmembrane

Purification

Immunogen affinity purified.

Form

Liquid

Function

This protein may be involved in the regulation of B-cell activation and proliferation.

References & Citations

1. Cragg MS, Walshe CA, Ivanov AO, Glennie MJ (2005) . The biology of CD20 and its potential as a target for mAb therapy. Curr. Dir. Autoimmun. Current ions in Autoimmunity 8: 140–74. 2. Hardy, Richard (2008) . Chapter 7: B Lymphocyte Development and Biology. In Paul, William.Fundamental Immunology (Book) (6th ed.) . Philadelphia: Lippincott Williams & Wilkins. pp. 237–269. 3. Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA (January 2010) . CD20 deficiency in humans results in impaired T cell-independent antibody responses. J. Clin. Invest. 120 (1) : 214–22.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

33077 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

B-lymphocyte antigen CD20

Subcellular Location

Cell membrane ; Multi-pass membrane protein . Cell membrane ; Lipid-anchor .

Sequence Similarities

Belongs to the MS4A family.

Protein Name

B-lymphocyte antigen CD20

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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