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Anti-Calbindin/CALB1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Calbindin is a calcium-binding protein belonging to the troponin C superfamily. Calretinin is expressed in central and peripheral nervous system and in many normal and pathological tissues. The rat and human calretinin exhibit 98% sequence homology and 91% homology to many other species. Two calcium binding proteins, calbindin and calretinin, have been reported to be expressed in abundance in Purkinje cells and other cell types in the cerebellum.

Synonyms

Calbindin; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type; CALB1; CAB27

Gene Name

CALB1

Gene ID

793

UniProt

P05937

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human Calbindin recombinant protein (Position: A2-E175) . Human Calbindin shares 99% amino acid (aa) sequence identity with both mouse and rat Calbindin.

Clonality

Polyclonal

Tissue Specificity

Expressed in all cell types so far analyzed.

Applications

Flow Cytometry

Field of Research

Calcium Binding Proteins, Calcium Signaling, Cell Type Marker, Neuron Marker, Neuroscience, Neurotransmission

Purification

Immunogen affinity purified.

Form

Liquid

Function

Buffers cytosolic calcium. May stimulate a membrane Ca (2+) -ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

References & Citations

1. Parmentier M.; The human calbindins: cDNA and gene cloning.; Adv. Exp. Med. Biol. 255:233-240 (1989) . 2. Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I., Hammer M., Jacobowitz D.M.; The mouse calretinin gene promoter region: structural and functional components.; Brain Res. Mol. Brain Res. 49:175-187 (1997) . 3. Gabrielides C., McCormack A.L., Hunt D.F., Christakos S.; Brain calbindin-D28k and an Mr 29,000 calcium binding protein in cerebellum are different but related proteins: evidence obtained from sequence analysis by tandem mass spectrometry.; Biochemistry 30:656-662 (1991) .

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

30 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Calbindin

Subcellular Location

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N-terminal PH domain, is recruited to sites of the plasma membrane containing increased PI (3,4,5) P3 or PI (3,4) P2, cell membrane targeting is also facilitared by interaction with CLIP3.

Sequence Similarities

Belongs to the calbindin family.

Protein Name

Calbindin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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