Anti-ARA9/AIP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
AIP, also known as, ARA9 or XAP-2, is a protein that in humans is encoded by the AIP gene. This gene is mapped to 11q13.2. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. AIP may play a positive role in aryl hydrocarbon receptor-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. It has been shown that AIP is the cellular negative regulator of the hepatitis B virus (HBV) X protein. AIP mutations may be the cause of a familial form of acromegaly, familial isolated pituitary adenoma (FIPA) .
Synonyms
AH receptor-interacting protein; AIP; Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; XAP-2; Immunophilin homolog ARA9; AIP; XAP2
Gene Name
AIP
Gene ID
9049
UniProt
O00170
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human ARA9 recombinant protein (Position: D91-H330) . Human ARA9 shares 95% amino acid (aa) sequence identity with both mouse and rat ARA9.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.
Applications
Flow Cytometry
Field of Research
Chaperones, Neuroscience, Protein Trafficking, Sensory System, Signal Transduction, Visual System
Purification
Immunogen affinity purified.
Form
Liquid
Function
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
References & Citations
1. Carver LA, Bradfield CA (April 1997) . Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. J. Biol. Chem. 272 (17) : 11452–6. 2. Kuzhandaivelu, N., Cong, Y.-S., Inouye, C., Yang, W.-M., Seto, E. XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. Nucleic Acids Res. 24: 4741-4750, 1996. 3. Occhi G, Trivellin G, Ceccato F, et al. (2010) . Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia.. Eur. J. Endocrinol. 163 (3) : 369–376.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
37636 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
AH receptor-interacting protein
Subcellular Location
Cytoplasm.
Sequence Similarities
Contains 1 PPIase FKBP-type domain.
Protein Name
AH receptor-interacting protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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