Anti-LIF Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
LIF is a pleiotropic cytokine produced at the maternal-fetal interface which has been shown to play an essential role in implantation in mice. This gene is mapped to 22q11-q12.2, between the Philadelphia translocation BCR gene and the breakpoint of the translocation in cell line GM2324 at 22q12.2. LIF is produced in high amounts by the human endometrium and the trophoblast itself, and LIF receptors are present on cytotrophoblast cells. LIF could, thus, play a role in modulating HLA-G production and immune tolerance at the maternal-fetal interface.
Synonyms
Leukemia inhibitory factor; LIF; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; Emfilermin; LIF; HILDA
Gene Name
LIF
Gene ID
3976
UniProt
P15018
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human LIF recombinant protein (Position: S23-F202) . Human LIF shares 78% and 82% amino acid (aa) sequences identity with mouse and rat LIF, respectively.
Clonality
Polyclonal
Tissue Specificity
Widely distributed in various tissues.
Applications
Flow Cytometry
Field of Research
Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Differentiation, Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Neurogenesis, Neurology Process, Neuroscience, Transcription, Tumor Suppressors
Purification
Immunogen affinity purified.
Form
Liquid
Function
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
References & Citations
1. Bamberger, A.-M., Jenatschke, S., Schulte, H. M., Loning, T., Bamberger, C. M. Leukemia inhibitory factor (LIF) stimulates the human HLA-G promoter in JEG3 choriocarcinoma cells. J. Clin. Endocr. Metab. 85: 3932-3936, 2000. 2. Sutherland, G. R., Baker, E., Hyland, V. J., Callen, D. F., Stahl, J., Gough, N. M. The gene for human leukemia inhibitory factor (LIF) maps to 22q12. Leukemia 3: 9-13, 1989.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
22008 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Leukemia inhibitory factor
Subcellular Location
Secreted.
Sequence Similarities
Belongs to the LIF/OSM family.
Protein Name
Leukemia inhibitory factor
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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