Anti-TARC/CCL17 Antibody Picoband® Fluoro647 Conjugated

Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC) . CCL17 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. The gene for CCL17 is located on chromosome 16, in humans, along with other chemokines called CCL22 and CX3CL1. The standard used in this kit is recombinant human CCL17, consisting of 71 amino acids with the molecular weight of 8Kda.

Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

1. Imai T, Yoshida T, Baba M, Nishimura M, Kakizaki M, Yoshie O (1996) . Molecular cloning of a novel T cell-ed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. J. Biol. Chem. 271 (35) : 21514–21. 2. Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (1997) . The T cell-ed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 272 (23) : 15036–42. 3. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1997) . Assignment of the human CC chemokine gene TARC (SCYA17) to chromosome 16q13. Genomics 40 (1) : 211–3. 4. Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998) . Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. Cytogenet. Cell Genet. 81 (1) : 10–1.