Anti-CaV1.3/CACNA1D Antibody Picoband®

Cav1.3, also known as the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), is a human gene. It is mapped to 3p21.1. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Alpha-1D subunit can mediate DHP-sensitive, high voltage-activated, long-lasting calcium channel activity. CACNA1D can form L-type calcium channels with negative activation thresholds which is essential for normal auditory function and controling of cardiac pacemaker activity.

Voltage-dependent L-type calcium channel subunit alpha-1D; Calcium channel, L type, alpha-1 polypeptide, isoform 2; Voltage-gated calcium channel subunit alpha Cav1.3; CACNA1D; CACH3, CACN4, CACNL1A2, CCHL1A2

A synthetic peptide corresponding to a sequence at the C-terminus of human CaV1.3, different from the related mouse and rat sequences by one amino acid.

Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. .

Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Neuroscience, Neurotransmission, Pathways and Processes, Signal Transduction, Signaling Pathway

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA) . They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA) . .

1. Entrez Gene: CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 2. Platzer, J., Engel, J., Schrott-Fischer, A., Stephan, K., Bova, S., Chen, H., Zheng, H., Striessnig, J. Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca (2+) channels. Cell 102: 89-97, 2000. 3. Williams, M. E., Feldman, D. H., McCue, A. F., Brenner, R., Velicelebi, G., Ellis, S. B., Harpold, M. M. Structure and functional expression of alpha-1, alpha-2, and beta subunits of a novel human neuronal calcium channel subtype. Neuron 8: 71-84, 1992.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.