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Anti-ST5 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5 gene. This gene is mapped to 11p15.4. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.

Synonyms

Suppression of tumorigenicity 5 protein; DENN domain-containing protein 2B; HeLa tumor suppression 1; ST5; DENND2B, HTS1

Gene Name

ST5

Gene ID

6764

UniProt

P78524

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human ST5, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level) . Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cancer, MAPK Pathway, Oncoproteins/Suppressors, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth. .

References & Citations

1. Entrez Gene: ST5 suppression of tumorigenicity 5 2. Lichy JH, Modi WS, Seuanez HN, Howley PM (Nov 1992) . Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells.Cell Growth Differ 3 (8) : 541–8. 3. Trautmann, U., Vikkula, M., Winterpacht, A., FitzPatrick, D. R., Rauch, A. Disruption of ST5 is associated with mental retardation and multiple congenital abnormalities. J. Med. Genet. 47: 91-98, 2010.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

126485 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Suppression of tumorigenicity 5 protein

Sequence Similarities

Contains 1 dDENN domain.

Protein Name

Suppression of tumorigenicity 5 protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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