Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-MEK2/MAP2K2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2), also called PRKMK2 or MEK2, is an enzyme that in humans is encoded by the MAP2K2 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MAP2K2 is mapped to 19p13.3. This kinase is known to play a critical role in mitogen growth factor signal transduction, and the inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax. Recombinant MEK2 and MEK1 both could activate human ERK1 in vitro, and they further characterized biochemically the 2 MAP2Ks. MAP2K2 has been shown to interact with MAPK3 and ARAF.

Synonyms

Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2;2.7.12.2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2; MAP2K2; MEK2, MKK2, PRKMK2

Gene Name

MAP2K2

Gene ID

5605

UniProt

P36507

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human MEK2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Signaling Pathways, Stem Cells, Structures, Surface Molecules, Visual System

Purification

Immunogen affinity purified.

Form

Liquid

Function

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity) . .

References & Citations

1.“Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2 2. Zheng, C. F., Guan, K. L. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268: 11435-11439, 1993.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

44424 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Dual specificity mitogen-activated protein kinase kinase 2

Sequence Similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Protein Name

Dual specificity mitogen-activated protein kinase kinase 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rat Soluble endothelial protein C receptor (sEPCR) ELISA Kit
NSL0158r 96 Tests

Rat Soluble endothelial protein C receptor (sEPCR) ELISA Kit

Ask
View Details
Rabies (Rabies Virus) (APC)
MBS6127096-01 0.1 mL

Rabies (Rabies Virus) (APC)

Ask
View Details
Rabies (Rabies Virus) (APC)
MBS6127096-02 5x 0.1 mL

Rabies (Rabies Virus) (APC)

Ask
View Details
Mouse Monoclonal EXOSC3 Antibody (OTI1D6) [CoraFluor 1]
NBP2-71881CL1 0.1 mL

Mouse Monoclonal EXOSC3 Antibody (OTI1D6) [CoraFluor 1]

Ask
View Details
Taar2 Mouse qPCR Primer Pair (NM_001007266)
MP217057 200 Reactions

Taar2 Mouse qPCR Primer Pair (NM_001007266)

Ask
View Details
Human GRIN2B siRNA
abx902321-01 15 nmol

Human GRIN2B siRNA

Ask
View Details