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Anti-HNF1 beta/HNF1B Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

HNF1 homeobox B (hepatocyte nuclear factor 1 homeobox B), also known as HNF1B or transcription factor 2 (TCF2), is a human gene. It is a member of the homeodomain-containing superfamily of transcription factors. This gene is mapped to 17q12. The HNF1B protein is believed to form heterodimers with another liver-specific member of this transcription factor family, TCF1. HNF1B functions as both a classic transcriptional activator and as a bookmarking factor that marks target genes for rapid transcriptional reactivation after mitosis. HNF1B also can regulate renal tubulogenesis by controlling expression of SOC3. Mutation of HNF1B that disrupts normal function has been identified as the cause of MODY5 (Maturity-Onset of Diabetes, Type 5) .

Synonyms

Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1; HNF1B; TCF2

Gene Name

HNF1B

Gene ID

6928

UniProt

P35680

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human HNF1 beta, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Highest expression in brain, lower in heart, kidney, pancreas, placenta, lung and skeletal muscle.

Applications

Flow Cytometry

Field of Research

Diabetes, Epigenetics and Nuclear Signaling, Metabolism, Transcription

Purification

Immunogen affinity purified.

Form

Liquid

Function

Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.

References & Citations

1. Bach, I., Mattei, M.-G., Cereghini, S., Yaniv, M. Two members of an HNF1 homeoprotein family are expressed in human liver. Nucleic Acids Res. 19: 3553-3559, 1991. 2. Entrez Gene: TCF2 transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor 3. Verdeguer, F., Le Corre, S., Fischer, E., Callens, C., Garbay, S., Doyen, A., Igarashi, P., Terzi, F., Pontoglio, M. A mitotic transcriptional switch in polycystic kidney disease. (Letter) Nature Med. 16: 106-110, 2010.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

61324 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Hepatocyte nuclear factor 1-beta

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the HNF1 homeobox family.

Protein Name

Hepatocyte nuclear factor 1-beta

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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