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Anti-TNFAIP8L3 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

TNFAIP8L3 belongs to the TNFAIP8 family. It acts as a negative mediator of apoptosis and may play a role in tumor progression. This gene suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

Synonyms

Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3; TNFAIP8L3

Gene Name

TNFAIP8L3

Gene ID

388121

UniProt

Q5GJ75

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human TNFAIP8L3, different from the related mouse and rat sequences by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Plasma, associated with HDL (at protein level) . Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. .

Applications

Flow Cytometry

Field of Research

Cell Biology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. .

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

32659 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Tumor necrosis factor alpha-induced protein 8-like protein 3

Subcellular Location

Secreted, extracellular space.

Sequence Similarities

Belongs to the TNFAIP8 family.

Protein Name

Tumor necrosis factor alpha-induced protein 8-like protein 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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