Anti-Glutamate receptor 3/GRIA3 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. It is mapped to Xq25. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. In addition to that, GRIA3 has been shown to interact with GRIP1 and PICK1.
Synonyms
Glutamate receptor 3; GluR-3; AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3; GRIA3; GLUR3, GLURC
Gene Name
GRIA3
Gene ID
2892
UniProt
P42263
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human GRIA3, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Amino Acids, G Protein Signaling, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Neurotransmitter, Receptors / Channels, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. .
References & Citations
1. Entrez Gene: GRIA3 glutamate receptor, ionotrophic, AMPA 3 2. Hirbec, Hélène; Perestenko Olga, Nishimune Atsushi, Meyer Guido, Nakanishi Shigetada, Henley Jeremy M, Dev Kumlesh K (May 2002) . The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J. Biol. Chem. (United States) 277 (18) : 15221–4. 3. McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF (Jul 1992) . Chromosomal localization of human glutamate receptor genes. J Neurosci 12 (7) : 2555–62.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
101157 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Glutamate receptor 3
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Interaction with CNIH2 and CNIH3 promotes cell surface expression. .
Sequence Similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.
Protein Name
Glutamate receptor 3
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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