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Anti-Vasopressin V1a receptor AVPR1A Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PA2248-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Arginine vasopressin receptor 1A (officially called AVPR1A) is one of the three major receptor types for  arginine vasopressin  (AVPR1B  and  AVPR2  being the others) . It belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. This gene is mapped to 12q14.2. AVPR1A is present throughout the brain, as well as in the periphery, in the liver, kidney, and vasculature. The protein encoded by this gene acts as receptor for arginine vasopressin. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis.

Synonyms

Vasopressin V1a receptor; V1aR; AVPR V1a; Antidiuretic hormone receptor 1a; Vascular/hepatic-type arginine vasopressin receptor; Avpr1a

Gene Name

AVPR1A

Gene ID

25107

UniProt

P30560

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of rat AVPR1A, different from the related human and mouse sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Localized within gonadotropes of the anterior pituitary of the brain. Broadly distributed throughout the cerebral cortex. .

Applications

Flow Cytometry

Field of Research

G Protein Signaling, More Gpcr, Neurology Process, Neuroscience, Neurotransmission, Receptors / Channels, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation. .

References & Citations

1. Birnbaumer, M. Vasopressin receptors. Trends Endocr. Metab. 11: 406-410, 2000. 2. Caldwell HK, Lee HJ, Macbeth AH, Young WS (2008) . Vasopressin: behavioral roles of an ‘original’ neuropeptide. Prog Neurobiol 84 (1) : 1–24.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

47655 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Vasopressin V1a receptor

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Located in cytoplasmic vesicles dispersed throughout the cell cytoplasm and to the plasma membrane.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein Name

Vasopressin V1a receptor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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