Anti-DNA/RNA-binding protein KIN17 KIN Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
DNA/RNA-binding protein KIN17, also known as BTCD or KIN17 is a protein that in humans is encoded by the KIN gene. This gene is mapped to 10p14. The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants.
Synonyms
DNA/RNA-binding protein KIN17; Binding to curved DNA; KIN, antigenic determinant of recA protein homolog; KIN ; BTCD, KIN17
Gene Name
KIN
Gene ID
22944
UniProt
O60870
Host
Rabbit
Reactivity
Rat, Mouse, Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human KIN, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at protein level) . .
Applications
Flow Cytometry
Field of Research
DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity) . Binds via its C-terminal domain to RNA in vitro. .
References & Citations
1. Kannouche, P., Mauffrey, P., Pinon-Lataillade, G., Mattei, M. G., Sarasin, A., Daya-Grosjean, L., Angulo, J. F. Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans. Carcinogenesis 21: 1701-1710, 2000. 2. Timchenko, T., Bailone, A., Devoret, R. Btcd, a mouse protein that binds to curved DNA, can substitute in Escherichia coli for H-NS, a bacterial nucleoid protein. EMBO J. 15: 3986-3992, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
45374 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
DNA/RNA-binding protein KIN17
Subcellular Location
Nucleus . Cytoplasm . During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. .
Sequence Similarities
Belongs to the KIN17 family.
Protein Name
DNA/RNA-binding protein KIN17
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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