Anti-Prospero homeobox protein 1 PROX1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Prospero homeobox protein 1, also called PROX1 is a protein that in humans is encoded by the PROX1 gene. This gene is mapped to 1q32.3. The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus.
Synonyms
Prospero homeobox protein 1; Homeobox prospero-like protein PROX1; PROX-1; PROX1
Gene Name
PROX1
Gene ID
5629
UniProt
Q92786
Host
Rabbit
Reactivity
Rat, Mouse, Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human PROX1, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. .
Applications
Flow Cytometry
Field of Research
Cardiogenesis, Cardiovascular, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neural Signal Transduction, Neurology Process, Neuroscience, Transcription, Transcription Factors/Regulators
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. .
References & Citations
1. Dyer, M. A., Livesey, F. J., Cepko, C. L., Oliver, G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nature Genet. 34: 53-58, 2003. 2. Harvey, N. L., Srinivasan, R. S., Dillard, M. E., Johnson, N. C., Witte, M. H., Boyd, K., Sleeman, M. W., Oliver, G. Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nature Genet. 37: 1072-1081, 2005. 3. Kazenwadel, J., Michael, M. Z., Harvey, N. L. Prox1 expression is negatively regulated by miR-181 in endothelial cells. Blood 116: 2395-2401, 2010.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
83203 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Prospero homeobox protein 1
Subcellular Location
Nucleus . RORG promotes its nuclear localization. .
Sequence Similarities
Belongs to the Prospero homeobox family.
Protein Name
Prospero homeobox protein 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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