Anti-Calponin/CNN1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Calponin is a basic 34-kD protein first isolated from chicken gizzard and bovine aorta. This gene is mapped to 19p13.2. It is specifically expressed in smooth muscle and binds calmodulin, actin, and tropomyosin. It is able to inhibit the ATPase activity of myosin and is though to play a role in smooth muscle contraction. Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-binding protein though to be involved in some way in the regulation or modulation of contraction.
Synonyms
Calponin-1; Basic calponin; Calponin H1, smooth muscle; CNN1
Gene Name
CNN1
Gene ID
1264
UniProt
P51911
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Calponin, different from the related mouse and rat sequences by two amino acids.
Clonality
Polyclonal
Tissue Specificity
Smooth muscle, and tissues containing significant amounts of smooth muscle.
Applications
Flow Cytometry
Field of Research
Actin Binding Proteins, Actin, etc., Cardiovascular, Cytoskeleton, Cytoskeleton/ECM, Mesenchymal Stem Cells, Microfilaments, Signal Transduction, Stem Cells, Vasculature
Purification
Immunogen affinity purified.
Form
Liquid
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity) . .
References & Citations
1. Miano, J. M., Krahe, R., Garcia, E., Elliott, J. M., Olson, E. N. Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene. Gene 197: 215-224, 1997. 2. Miano, J. M., Thomas, S., Disteche, C. M. Expression and chromosomal mapping of the mouse smooth muscle calponin gene. Mammalian Genome 12: 187-191, 2001. 3. Strasser, P., Gimona, M., Moessler, H., Herzog, M., Small, J. V. Mammalian calponin: identification and expression of genetic variants. FEBS Lett. 330: 13-18, 1993.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
33170 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Calponin-1
Subcellular Location
Nucleus . Cytoplasm . Accumulates in aggresomes under proteasome inhibition conditions.
Sequence Similarities
Belongs to the calponin family.
Protein Name
Calponin-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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