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Anti-LI-Cadherin-17 CDH17-Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Cadherin-17, also known as HPT1 or CDH16 is a protein that in humans is encoded by the CDH17 gene. By somatic cell hybrid analysis and fluorescence in situ hybridization, CDH17 gene is mapped to 8q22.1. This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.

Synonyms

Cadherin-17; Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin; LI-cadherin; CDH17

Gene Name

CDH17

Gene ID

1015

UniProt

Q12864

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human LI Cadherin.

Clonality

Polyclonal

Tissue Specificity

Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. .

Applications

Flow Cytometry

Field of Research

Cadherins, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. .

References & Citations

1. Dantzig, A. H., Hoskins, J., Tabas, L. B., Bright, S., Shepard, R. L., Jenkins, I. L., Duckworth, D. C., Sportsman, J. R., Mackensen, D., Rosteck, P. R., Jr., Skatrud, P. L. Association of intestinal peptide transport with a protein related to the cadherin superfamily. cience 264: 430-433, 1994. 2. Kremmidiotis, G., Baker, E., Crawford, J., Eyre, H. J., Nahmias, J., Callen, D. F. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. Genomics 49: 467-471, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

92219 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Cadherin-17

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Sequence Similarities

Contains 7 cadherin domains.

Protein Name

Cadherin-17

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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