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Anti-Nucleolysin TIA-1 isoform p40 TIA1 Antibody Picoband® Fluoro488 Conjugated

Selected Variant

PA2194-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

TIA1, also called WDM, encodes an RNA-binding protein involved in splicing regulation and translational repression. The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. By in situ hybridization, this gene is mapped to chromosome 2p13.3. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is though to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.

Synonyms

Nucleolysin TIA-1 isoform p40; RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA-1; p40-TIA-1; TIA1

Gene Name

TIA1

Gene ID

7072

UniProt

P31483

Host

Rabbit

Reactivity

Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human TIA1, identical to the related mouse sequence.

Clonality

Polyclonal

Tissue Specificity

Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Apoptosis, Cancer, Cell Biology, Cell Death, DNA/RNA, Epigenetics and Nuclear Signaling, Immunology, Non-CD, Nucleus, RNA Processing, T Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs) . Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

References & Citations

1. Hackman, P., Sarparanta, J., Lehtinen, S., Vihola, A., Evila, A., Jonson, P. H., Luque, H., Kere, J., Screen, M., Chinnery, P. F., Ahlberg, G., Edstrom, L., Udd, B. Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1. Ann. Neurol. 73: 500-509, 2013. 2. Klar, J., Sobol, M., Melberg, A., Mabert, K., Ameur, A., Johansson, A. C. V., Feuk, L., Entesarian, M., Orlen, H., Casar-Borota, O., Dahl, N. Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing. Hum. Mutat. 34: 572-577, 2013.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

42963 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Nucleolysin TIA-1 isoform p40

Subcellular Location

Cytoplasmic granule. Nucleus. Accumulates in cytoplasmic stress granules (SG) following cellular damage.

Sequence Similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Protein Name

Nucleolysin TIA-1 isoform p40

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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