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Anti-Monocarboxylate transporter 5 SLC16A4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Monocarboxylate transporter 5, also called Solute carrier family 16 member 4 or MCT4, is a protein that in humans is encodes by the SLC16A4 gene. This gene is mapped to 1p13.3. It acts as the proton-linked monocarboxylate transporter. This gene catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.

Synonyms

Monocarboxylate transporter 5; MCT 5; Monocarboxylate transporter 4; MCT 4; Solute carrier family 16 member 4; SLC16A4; MCT4, MCT5

Gene Name

SLC16A4

Gene ID

9122

UniProt

O15374

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human SLC16A4, different from the related rat and mouse sequences by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined.

Applications

Flow Cytometry

Field of Research

Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) . .

References & Citations

1. Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., Wu, J., Chang, D. K., Cowley, M. J., and 116 others. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491: 399-405, 2012. 2. Yoon, H., Donoso, L. A., Philp, N. J. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. Genomics 60: 366-370, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

54022 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Monocarboxylate transporter 5

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Protein Name

Monocarboxylate transporter 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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