Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hyaluronidase-1 HYAL1 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

PA2181-2-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

Synonyms

Hyaluronidase-1; Hyal-1;3.2.1.35; Hyaluronoglucosaminidase-1; Hyal1

Gene Name

HYAL1

Gene ID

15586

UniProt

Q91ZJ9

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse HYAL1, different from the related rat sequence by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in liver, kidney, lung and skin. .

Applications

Flow Cytometry

Field of Research

Cancer, Cytoskeleton/ECM, ECM Enzymes, ECM Proteins, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. .

References & Citations

1. Csoka, A. B., Frost, G. I., Heng, H. H. Q., Scherer, S. W., Mohapatra, G., Stern, R. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. Genomics 48: 63-70, 1998. Note: Erratum: Genomics 84: 227 only, 2004. 2. Martin, D. C., Atmuri, V., Hemming, R. J., Farley, J., Mort, J. S., Byers, S., Hombach-Klonisch, S., Csoka, A. B., Stern, R., Triggs-Raine, B. L. A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis. Hum. Molec. Genet. 17: 1904-1915, 2008. Note: Erratum: Hum. Molec. Genet. 17: 2919 only, 2008.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

52109 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Hyaluronidase-1

Subcellular Location

Secreted . Lysosome .

Sequence Similarities

Belongs to the glycosyl hydrolase 56 family.

Protein Name

Hyaluronidase-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Anti-G-CSF/CSF3 Antibody Picoband® (iFluor647 Conjugate)
PB9577-iFluor647 100 µg

Anti-G-CSF/CSF3 Antibody Picoband® (iFluor647 Conjugate)

Sign In for Pricing
View Details
Anti-VIP Receptor 1/VIPR1 Antibody Picoband®, Dylight550 Conjugate
PA1756-Dylight550 100 µg

Anti-VIP Receptor 1/VIPR1 Antibody Picoband®, Dylight550 Conjugate

Sign In for Pricing
View Details
Gastrin Recombinant Rabbit Monoclonal Antibody [PD00-37]
HA721159 100 µL

Gastrin Recombinant Rabbit Monoclonal Antibody [PD00-37]

Sign In for Pricing
View Details
ZFYVE28 (Zinc Finger FYVE-type containing 28) (LST2/2426), CF568 conjugate, 0.1mg/mL
BNC682426-500 1x 500 µL

ZFYVE28 (Zinc Finger FYVE-type containing 28) (LST2/2426), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Human Lambda Light Chain (B-Cell Marker) (LLC/3778R), CF568 conjugate, 0.1mg/mL
BNC683778-500 1x 500 µL

Human Lambda Light Chain (B-Cell Marker) (LLC/3778R), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
GATA-3 (Breast and Urothelial Marker) (GATA3/2444), CF405S conjugate, 0.1mg/mL
BNC042444-100 1x 100 µL

GATA-3 (Breast and Urothelial Marker) (GATA3/2444), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details