Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-SLC12A6 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Solute carrier family 12 (potassium/chloride transporters), member 6, also called SLC12A6 or KCC3, is a protein that in humans is encoded by the SLC12A6 gene. This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. By radiation hybrid and somatic cell hybrid analyses, this gene is mapped to 15q14. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

Synonyms

Solute carrier family 12 member 6; Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3; SLC12A6; KCC3

Gene Name

SLC12A6

Gene ID

9990

UniProt

Q9UHW9

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC12A6, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level) . .

Applications

Flow Cytometry

Field of Research

Neurogenesis, Neurology Process, Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

Purification

Immunogen affinity purified.

Form

Liquid

Function

Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.

References & Citations

1. Howard, H. C., Mount, D. B., Rochefort, D., Byun, N., Dupre, N., Lu, J., Fan, X., Song, L., Riviere, J.-B., Prevost, C., Horst, J., Simonati, A., and 12 others. The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum. Nature Genet. 32: 384-392, 2002. Note: Erratum: Nature Genet. 32: 681 only, 2002. 2. Salin-Cantegrel, A., Riviere, J.-B., Shekarabi, M., Rasheed, S., DaCal, S., Laganiere, J., Gaudet, R., Rochefort, D., Lesca, G., Gaspar, C., Dion, P. A., Lapointe, J.-Y., Rouleau, G. A.Transit defect of potassium-chloride co-transporter 3 is a major pathogenic mechanism in hereditary motor and sensory neuropathy with agenesis of the corpus callosum. J. Biol. Chem. 286: 28456-28465, 2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

127617 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Solute carrier family 12 member 6

Subcellular Location

Basolateral cell membrane ; Multi-pass membrane protein .

Protein Name

Solute carrier family 12 member 6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Recombinant Jagged 2 Antibody
RC-16304-01 50 μL

Recombinant Jagged 2 Antibody

Ask
View Details
Recombinant Jagged 2 Antibody
RC-16304-02 100 µL

Recombinant Jagged 2 Antibody

Ask
View Details
Recombinant Jagged 2 Antibody
RC-16304-03 1 mL

Recombinant Jagged 2 Antibody

Ask
View Details
Phf11d Mouse shRNA Lentiviral Particle (Locus ID 219132)
TL506601V 500 µL Each

Phf11d Mouse shRNA Lentiviral Particle (Locus ID 219132)

Ask
View Details
Lipopolysaccharide (LPS) Antibody Pair
abx370918-01 5x 96 Tests

Lipopolysaccharide (LPS) Antibody Pair

Ask
View Details
Lipopolysaccharide (LPS) Antibody Pair
abx370918-02 10x 96 Tests

Lipopolysaccharide (LPS) Antibody Pair

Ask
View Details