Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-GLUT12/SLC2A12 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Solute carrier family 2, facilitated glucose transporter member 12, also known as SLC2A12, is a protein that in humans is encoded by the SLC2A12 gene. SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion. This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues. By genomic sequence analysis, this gene is mapped to chromosome 6q23.2. SLC2A12 was detected in a perinuclear location in MCF7 cells in the absence of insulin; however, SLC2A12 redistributed to the plasma membrane of MCF7 cells grown continuously in the presence of insulin. This gene acts as facilitative glucose transporter.

Synonyms

Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12; SLC2A12; GLUT12, GLUT8

Gene Name

SLC2A12

Gene ID

154091

UniProt

Q8TD20

Host

Rabbit

Reactivity

Rat, Mouse, Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human GLUT12, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney. .

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Diabetes, Diabetes-associated, Energy Metabolism, Energy Transfer Pathways, Heart Disease, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Facilitative glucose transporter. .

References & Citations

1. Linden, K. C., DeHaan, C. L., Zhang, Y., Glowacka, S., Cox, A. J., Kelly, D. J., Rogers, S.Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. Am. J. Physiol. Renal Physiol. 290: F205-F213, 2006. 2. Wood, I. S., Hunter, L., Trayhurn, P. Expression of class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues. Biochem. Biophys. Res. Commun. 308: 43-49, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

66966 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Solute carrier family 2, facilitated glucose transporter member 12

Subcellular Location

Endomembrane system ; Multi- pass membrane protein . Cytoplasm, perinuclear region . Localizes primarily perinuclear region in the absence of insulin.

Sequence Similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Protein Name

Solute carrier family 2, facilitated glucose transporter member 12

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

MYL1 Protein Vector (Mouse) (pPB-C-His)
PV203462 500 ng

MYL1 Protein Vector (Mouse) (pPB-C-His)

Sign In for Pricing
View Details
RO-5353
M11486-01 1 g

RO-5353

Sign In for Pricing
View Details
RO-5353
M11486-02 200 mg

RO-5353

Sign In for Pricing
View Details
RO-5353
M11486-03 500 mg

RO-5353

Sign In for Pricing
View Details
RO-5353
M11486-04 5 mg

RO-5353

Sign In for Pricing
View Details
RO-5353
M11486-05 50 mg

RO-5353

Sign In for Pricing
View Details