Anti-Gastrotropin FABP6 Antibody Picoband® Fluoro488 Conjugated

Fatty acid binding protein 6, ileal, also called FABP6 or ILBP is a protein which in humans is encoded by the FABP6 gene. Ileal lipid-binding protein (ILBP) is a member of a family of intracellular fatty acid, retinoid, and bile acid-binding proteins. This gene is mapped to 5q33.3. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is though that FABPs roles include fatty acid uptake, transport, and metabolism.

Gastrotropin; GT; Fatty acid-binding protein 6; Ileal lipid-binding protein; ILBP; Intestinal 15 kDa protein; I-15P; Intestinal bile acid-binding protein; I-BABP; FABP6; ILBP, ILLBP

Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level) . Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. .

Cancer, Cancer Metabolism, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction, Tumor Biomarkers

Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. .

1. Birkenmeier, E. H., Rowe, L. B., Crossman, M. W., Gordon, J. I. Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. Mammalian Genome 5: 805-806, 1994. 2. Oelkers, P., Dawson, P. A. Cloning and chromosomal localization of the human ileal lipid-binding protein. Biochim. Biophys. Acta 1257: 199-202, 1995.