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Anti-EIF2S2 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Eukaryotic translation initiation factor 2 subunit 2, also called EIF2S2 is a protein that in humans is encoded by the EIF2S2 gene. This gene belongs to the EIF-2-beta family. EIF2S2 is mapped to 20q11.2. Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.

Synonyms

Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eIF-2-beta; EIF2S2; EIF2B

Gene Name

EIF2S2

Gene ID

8894

UniProt

P20042

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human EIF2S2, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Found in all tissue examined including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Applications

Flow Cytometry

Field of Research

DNA/RNA, Epigenetics and Nuclear Signaling, Translation

Purification

Immunogen affinity purified.

Form

Liquid

Function

EIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

References & Citations

1. Heaney, J. D., Michelson, M. V., Youngren, K. K., Lam, M.-Y. J., Nadeau, J. H. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum. Molec. Genet. 18: 1395-1404, 2009. 2. Jennings, M. D., Pavitt, G. D. eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. Nature 465: 378-381, 2010. Note: Erratum: Nature 468: 122 only, 2010.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

38388 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Eukaryotic translation initiation factor 2 subunit 2

Subcellular Location

Nucleus.

Sequence Similarities

Belongs to the E2F/DP family.

Protein Name

Eukaryotic translation initiation factor 2 subunit 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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