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Anti-TRAF5 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

TNF receptor-associated factor 5, also known as RNF84, is a protein that in humans is encoded by the TRAF5 gene. The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family. Fluorescence in situ hybridization confirmed the regional localization of human TRAF5 to chromosome 1q32.2-q32.3. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. It is an adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. It seems to be involved in apoptosis.

Synonyms

TNF receptor-associated factor 5; RING finger protein 84; TRAF5; RNF84

Gene Name

TRAF5

Gene ID

7188

UniProt

O00463

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human TRAF5, different from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Applications

Flow Cytometry

Field of Research

Cytokines, Immunology, Innate Immunity, TNF Superfamily

Purification

Immunogen affinity purified.

Form

Liquid

Function

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. .

References & Citations

1. Kraus, Z. J., Nakano, H., Bishop, G. A. TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40. Proc. Nat. Acad. Sci. 106: 17140-17145, 2009. 2. So, T., Salek-Ardakani, S., Nakano, H., Ware, C. F., Croft, M. TNF receptor-associated factor 5 limits the induction of Th2 immune responses. J. Immun. 172: 4292-4297, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

64406 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

TNF receptor-associated factor 5

Subcellular Location

Cytoplasm . Cytoplasm, cytosol .

Sequence Similarities

Belongs to the TNF receptor-associated factor family. A subfamily.

Protein Name

TNF receptor-associated factor 5

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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