Anti-Protein NDRG2 NDRG2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Protein NDRG2, also known as KIAA1248, is a protein that in humans is encoded by the NDRG2 gene. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. This gene is mapped to 14q11.2. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. It contributes to the regulation of the WNT signaling pathway. This gene may be involved in dendritic cell and neuron differentiation.
Synonyms
Protein NDRG2; N-myc downstream-regulated gene 2 protein; Protein Syld709613; NDRG2; KIAA1248, SYLD
Gene Name
NDRG2
Gene ID
57447
UniProt
Q9UN36
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human NDRG2.
Clonality
Polyclonal
Tissue Specificity
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level) . .
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Cell Differentiation, Neurodegenerative Disease, Neurogenesis, Neurology Process, Neuroscience, Oncoproteins/Suppressors, Tumor Suppressors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. .
References & Citations
1. Kalaydjieva, L., Gresham, D., Gooding, R., Heather, L., Baas, F., de Jonge, R., Blechschmidt, K., Angelicheva, D., Chandler, D., Worsley, P., Rosenthal, A., King, R. H. M., Thomas, P. K. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. Am. J. Hum. Genet. 67: 47-58, 2000. 2. Li, Y., Yang, J., Li, S., Zhang, J., Zheng, J., Hou, W., Zhao, H., Guo, Y., Liu, X., Dou, K., Situ, Z., Yao, L. N-myc downstream-regulated gene 2, a novel estrogen-targeted gene, is involved in the regulation of Na+/K (+) -ATPase. J. Biol. Chem. 286: 32289-32299, 2011.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
41 kDa
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Protein NDRG2
Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone . In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity) . .
Sequence Similarities
Belongs to the NDRG family.
Protein Name
Protein NDRG2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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