What sizes are available for Anti-Protein NDRG2 NDRG2 Antibody Picoband® Fluoro594 Conjugated?

Anti-Protein NDRG2 NDRG2 Antibody Picoband® Fluoro594 Conjugated is available in the following size(s): 100 µg/Vial.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Anti-Protein NDRG2 NDRG2 Antibody Picoband® Fluoro594 Conjugated

Q: What is the catalog number for Anti-Protein NDRG2 NDRG2 Antibody Picoband® Fluoro594 Conjugated?

The catalog number for Anti-Protein NDRG2 NDRG2 Antibody Picoband® Fluoro594 Conjugated is PA2148-Fluoro594.

Selected Variant

PA2148-Fluoro594

Size: 100 µg/Vial

Product Specifications

Background

Protein NDRG2, also known as KIAA1248, is a protein that in humans is encoded by the NDRG2 gene. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. This gene is mapped to 14q11.2. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. It contributes to the regulation of the WNT signaling pathway. This gene may be involved in dendritic cell and neuron differentiation.

Synonyms

Protein NDRG2; N-myc downstream-regulated gene 2 protein; Protein Syld709613; NDRG2; KIAA1248, SYLD

Gene Name

NDRG2

Gene ID

57447

UniProt

Q9UN36

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human NDRG2.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level) . .

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, Neurodegenerative Disease, Neurogenesis, Neurology Process, Neuroscience, Oncoproteins/Suppressors, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. .

References & Citations

1. Kalaydjieva, L., Gresham, D., Gooding, R., Heather, L., Baas, F., de Jonge, R., Blechschmidt, K., Angelicheva, D., Chandler, D., Worsley, P., Rosenthal, A., King, R. H. M., Thomas, P. K. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. Am. J. Hum. Genet. 67: 47-58, 2000. 2. Li, Y., Yang, J., Li, S., Zhang, J., Zheng, J., Hou, W., Zhao, H., Guo, Y., Liu, X., Dou, K., Situ, Z., Yao, L. N-myc downstream-regulated gene 2, a novel estrogen-targeted gene, is involved in the regulation of Na+/K (+) -ATPase. J. Biol. Chem. 286: 32289-32299, 2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Protein NDRG2

Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone . In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity) . .

Sequence Similarities

Belongs to the NDRG family.

Protein Name

Protein NDRG2

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Anti-Cathepsin B/CTSB Antibody Picoband®, APC Conjugate

PB9046-APC 100 µg/Vial