Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Macrophage metalloelastase MMP12 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Matrix metalloproteinase-12 (MMP12), also known as MME or ME, is an enzyme that in humans is encoded by the MMP12 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.2. It is though that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. This gene may involved in tissue injury and remodeling.

Synonyms

Macrophage metalloelastase; MME;3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12; MMP12; HME

Gene Name

MMP12

Gene ID

4321

UniProt

P39900

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MMP12.

Clonality

Polyclonal

Tissue Specificity

Found in alveolar macrophages but not in peripheral blood monocytes.

Applications

Flow Cytometry

Field of Research

Angiogenesis, Atherosclerosis, Cancer, Cardiovascular, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

References & Citations

1. Houghton, A. M., Hartzell, W. O., Robbins, C. S., Gomis-Ruth, F. X., Shapiro, S. D.Macrophage elastase kills bacteria within murine macrophages. Nature 460: 637-641, 2009. 2. Joos, L., He, J.-Q., Shepherdson, M. B., Connett, J. E., Anthonisen, N. R., Pare, P. D., Sandford, A. J. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum. Molec. Genet. 11: 569-576, 2002. Note: Erratum: Hum. Molec. Genet. 12: 803-804, 2003. 3. Wu, L., Tanimoto, A., Murata, Y., Sasaguri, T., Fan, J., Sasaguri, Y., Watanabe, T. Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells.Genes Cells 8: 225-234, 2003.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

54002 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Macrophage metalloelastase

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Sequence Similarities

Belongs to the peptidase M10A family.

Protein Name

Macrophage metalloelastase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

Gm4763 3'UTR Luciferase Stable Cell Line
TU108096 1.0 mL

Gm4763 3'UTR Luciferase Stable Cell Line

Sign In for Pricing
View Details
C18orf21 Protein Vector (Human) (pPB-His-GST)
PV329479 500 ng

C18orf21 Protein Vector (Human) (pPB-His-GST)

Sign In for Pricing
View Details
FAM3C2 3'UTR GFP Stable Cell Line
TU057222 1.0 mL

FAM3C2 3'UTR GFP Stable Cell Line

Sign In for Pricing
View Details
EphA4, CT (Ephrin Type-A Receptor 4, Tyrosine-protein Kinase Receptor SEK, HEK8, EPH-like Kinase 8, EK8, Tyrosine-protein Kinase TYRO1, HEK8, SEK, TYRO1) (AP) discontinued
E3362-01L-AP 200 µL

EphA4, CT (Ephrin Type-A Receptor 4, Tyrosine-protein Kinase Receptor SEK, HEK8, EPH-like Kinase 8, EK8, Tyrosine-protein Kinase TYRO1, HEK8, SEK, TYRO1) (AP) discontinued

Sign In for Pricing
View Details
Lentiviral mouse Gzme shRNA (UAS) - Lentiviral mouse Gzme shRNA (UAS, RFP) (25)
GTR15236699 1 Vial

Lentiviral mouse Gzme shRNA (UAS) - Lentiviral mouse Gzme shRNA (UAS, RFP) (25)

Sign In for Pricing
View Details
Mbnl1 (BC096600) Mouse Recombinant Protein
TP503170 20 µg

Mbnl1 (BC096600) Mouse Recombinant Protein

Sign In for Pricing
View Details