Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Collagen II/COL2A1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Collagen, type II, alpha 1, also known as COL2A1, is a human gene which is the major collagen synthesized by chondrocvtes. COL2A1 is mapped to 12q13.11. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.

Synonyms

Collagen alpha-1 (II) chain; Alpha-1 type II collagen; Collagen alpha-1 (II) chain; Chondrocalcin; COL2A1

Gene Name

COL2A1

Gene ID

1280

UniProt

P02458

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen II, different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.

Clonality

Polyclonal

Tissue Specificity

Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte. .

Applications

Flow Cytometry

Field of Research

Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Mesenchymal Stem Cells, Signal Transduction, Stem Cells, Structures

Purification

Immunogen affinity purified.

Form

Liquid

Function

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

References & Citations

1. Donahue, L. R., Chang, B., Mohan, S., Miyakoshi, N., Wergedal, J. E., Baylink, D. J., Hawes, N. L., Rosen, C. J., Ward-Bailey, P., Zheng, Q. Y., Bronson, R. T., Johnson, K. R., Davisson, M. T. A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis. J. Bone Miner. Res. 18: 1612-1621, 2003. Note: Erratum: J. Bone Miner. Res. 22: 2011 only, 2007. 2. Faivre, L., Le Merrer, M., Douvier, S., Laurent, N., Thauvin-Robinet, C., Rousseau, T., Vereecke, I., Sagot, P., Delezoide, A.-L., Coucke, P., Mortier, G. Recurrence of achondrogenesis type II within the same family: evidence for germline mosaicism. Am. J. Med. Genet. 126A: 308-312, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

141785 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Collagen alpha-1 (II) chain

Subcellular Location

Secreted, extracellular space, extracellular matrix .

Sequence Similarities

Belongs to the fibrillar collagen family.

Protein Name

Collagen alpha-1 (II) chain

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human IL20RA shRNA Plasmid
abx959987-01 150 µg

Human IL20RA shRNA Plasmid

Sign In for Pricing
View Details
Human IL20RA shRNA Plasmid
abx959987-02 300 µg

Human IL20RA shRNA Plasmid

Sign In for Pricing
View Details
PPP2R2A Protein Vector (Human) (pPB-C-His)
PV032529 500 ng

PPP2R2A Protein Vector (Human) (pPB-C-His)

Sign In for Pricing
View Details
Rabbit Polyclonal Contactin-2/TAG1 Antibody [Alexa Fluor 532]
NBP2-99312AF532 0.1 mL

Rabbit Polyclonal Contactin-2/TAG1 Antibody [Alexa Fluor 532]

Sign In for Pricing
View Details
Recombinant Human Synaptobrevin homolog YKT6 (YKT6)
MBS1077152-01 0.02 mg (E-Coli)

Recombinant Human Synaptobrevin homolog YKT6 (YKT6)

Sign In for Pricing
View Details
Recombinant Human Synaptobrevin homolog YKT6 (YKT6)
MBS1077152-02 0.1 mg (E-Coli)

Recombinant Human Synaptobrevin homolog YKT6 (YKT6)

Sign In for Pricing
View Details