Anti-Cdc37 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Hsp90 co-chaperone Cdc37, also called P50CDC37 is a protein that in humans is encoded by the CDC37 gene. The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This gene is mapped to 19p13.2. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is though to play a critical role in ing Hsp90 to its target kinases.
Synonyms
Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; CDC37; CDC37A
Gene Name
CDC37
Gene ID
11140
UniProt
Q16543
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Cdc37, different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Epigenetics and Nuclear Signaling, Kinases/Phosphatases
Purification
Immunogen affinity purified.
Form
Liquid
Function
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. .
References & Citations
1. Chen, G., Cao, P., Goeddel, D. V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Molec. Cell 9: 401-410, 2002. 2. Vaughan, C. K., Mollapour, M., Smith, J. R., Truman, A., Hu, B., Good, V. M., Panaretou, B., Neckers, L., Clarke, P. A., Workman, P., Piper, P. W., Prodromou, C., Pearl, L. H.Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molec. Cell 31: 886-895, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
44468 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Hsp90 co-chaperone Cdc37
Subcellular Location
Cytoplasm .
Sequence Similarities
Belongs to the CDC37 family.
Protein Name
Hsp90 co-chaperone Cdc37
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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