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Anti-Protein Wnt-4 Wnt4 Antibody Picoband®

Boster Bio Anti-Protein Wnt-4 Wnt4 Antibody catalog # PA2121. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Wingless-type MMIV integration site family, member4, is a secreted protein that in humans is encoded by the Wnt4 gene. By fluorescence in situ hybridization, WNT4 gene was mapped to chromosome 1p35, a location consistent with the results of radiation hybrid mapping. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryogenesis.

Synonyms

Protein Wnt-4; WNT4; UNQ426/PRO864

Gene Name

WNT4

Gene ID

54361

UniProt

P56705

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Wnt4, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.

Applications

WB

Field of Research

Adapters, Cancer, Developmental Biology, Oncoproteins/Suppressors, Organogenesis, Reproduction, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Transmembrane, Tumor Suppressors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity) . Overexpression may be associated with abnormal proliferation in human breast tissue. .

References & Citations

1. Biason-Lauber, A., De Filippo, G., Konrad, D., Scarano, G., Nazzaro, A., Schoenle, E. J. WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum. Reprod. 22: 224-229, 2007. 2. Biason-Lauber, A., Konrad, D., Navratil, F., Schoenle, E. J. A WNT4 mutation associated with mullerian-duct regression and virilization in a 46, XX woman. New Eng. J. Med. 351: 792-798, 2004. 3. Garnis, C., Campbell, J., Davies, J. J., MacAulay, C., Lam, S., Lam, W. L. Involvement of multiple developmental genes on chromosome 1p in lung tumorigenesis. Hum. Molec. Genet. 14: 475-482, 2005.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

39052 MW

Observed Molecular Weight

37 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Protein Wnt-4

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Sequence Similarities

Belongs to the Wnt family.

Protein Name

Protein Wnt-4

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

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