Anti-Smad1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene. SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. The gene was assigned to human chromosome 4q31.21. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.
Synonyms
Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; Dwarfin-A; Dwf-A; Mothers-against-DPP-related 1; Mad-related protein 1; mMad1; SMAD family member 1; SMAD 1; Smad1; Smad1; Madh1, Madr1
Gene Name
SMAD1
Gene ID
17125
UniProt
P70340
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Smad1, different from the related rat sequence by one amino acid, and different from the related human sequence by two amino acids.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
Flow Cytometry
Field of Research
Cancer, Cancer Metabolism, Cytoplasmic, Epigenetics and Nuclear Signaling, Growth Factors, Metabolism, Metabolism Processes, Nuclear Signaling, Nuclear Signaling Pathways, Pathways and Processes, Response To Hypoxia, Signal Transduction, Signaling Pathway, Stem Cells, TGF Beta
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity) . May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity) . May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP) -mediated cardiac-specific gene expression (PubMed:15329343) . .
References & Citations
1. Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL (May 1996) . MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85 (4) : 489–500. 2. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996) . Mad-related genes in the human. Nat. Genet. 13 (3) : 347–9. 3. Entrez Gene: SMAD1 SMAD family member 1. 4. Interactive fly, Drosophila.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
52157 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Mothers against decapentaplegic homolog 1
Subcellular Location
Cytoplasm . Nucleus . In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Colocalizes with LEMD3 at the nucleus inner membrane (By similarity) . .
Sequence Similarities
Belongs to the dwarfin/SMAD family.
Protein Name
Mothers against decapentaplegic homolog 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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