Anti-Cystatin A/CSTA Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Cystatin A also called Stefin A is a protein that in humans is encoded by the CSTA gene. Cystatin A is a cysteine proteinase inhibitor that belongs to family 1 of the cystatin superpamily. This gene was assigned to human chromosome 3q21.1. This is an intracellular thiol proteinase inhibitor. Cystatin A plays an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. Stefins have been proposed as prognostic and diagnostic tools for cancer.
Synonyms
Cystatin-A; Cystatin-AS; Stefin-A; Cystatin-A, N-terminally processed; CSTA; STF1, STFA
Gene Name
CSTA
Gene ID
1475
UniProt
P01040
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Cystatin A.
Clonality
Polyclonal
Tissue Specificity
Expressed in the skin throughout the epidermis. .
Applications
Flow Cytometry
Field of Research
Apoptosis, Cancer, Caspases, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Intracellular, Invasion/Microenvironment, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. .
References & Citations
1. Blaydon, D. C., Nitoiu, D., Eckl, K.-M., Cabral, R. M., Bland, P., Hausser, I., van Heel, D. A., Rajpopat, S., Fischer, J., Oji, V., Zvulunov, A., Traupe, H., Hennies, H. C., Kelsell, D. P. Mutations in CSTA, encoding cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion. Am. J. Hum. Genet. 89: 564-571, 2011. 2. Samuelsson, L., Stiller, C., Friberg, C., Nilsson, C., Inerot, A., Wahlstrom, J.Association analysis of cystatin A and zinc finger protein 148, two genes located at the psoriasis susceptibility locus PSORS5. J. Invest. Derm. 122: 1399-1400, 2004. 3. Vasilopoulos, Y., Walters, J., Cork, M. J., Duff, G. W., Sagoo, G. S., Tazi-Ahnini, R.Association analysis of the skin barrier gene cystatin A at the PSORS5 locus in psoriatic patients: evidence for interaction between PSORS1 and PSORS5.Europ. J. Hum. Genet. 16: 1002-1009, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
11006 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Cystatin-A
Subcellular Location
Cytoplasm .
Sequence Similarities
Belongs to the cystatin family.
Protein Name
Cystatin-A
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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