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Anti-Caspase-12/CASP12 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Csp12L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of CSP12L expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.

Synonyms

Inactive caspase-12; CASP-12; CASP12; UNQ9415/PRO34398

Gene Name

CASP12

Gene ID

100506742

UniProt

Q6UXS9

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Caspase-12.

Clonality

Polyclonal

Tissue Specificity

Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. .

Applications

Flow Cytometry

Field of Research

Apoptosis, Cell Biology, Intracellular

Purification

Immunogen affinity purified.

Form

Liquid

Function

Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. .

References & Citations

1. Fischer, H., Koenig, U., Eckhart, L., Tschachler, E. Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 293: 722-726, 2002. 2. Saleh, M., Mathison, J. C., Wolinski, M. K., Bensinger, S. J., Fitzgerald, P., Droin, N., Ulevitch, R. J., Green D. R., Nicholson, D. W. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 440: 1064-1068, 2006. 3. Yeretssian, G., Doiron, K., Shao, W., Leavitt, B. R., Hayden, M. R., Nicholson, D. W., Saleh, M. Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection. Proc. Nat. Acad. Sci. 106: 9016-9020, 2009.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

38865 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Inactive caspase-12

Subcellular Location

Cytoplasm.

Sequence Similarities

Belongs to the peptidase C14A family.

Protein Name

Inactive caspase-12

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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