Anti-Bcl-2-related protein A1 Bcl2A1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Bcl-2-related protein A1 (BCL2A1), is the human homolog of the murine A1, and maps to chromosome 15q24.3. The BCL2A1 gene has also been referred to as BCL2L5, BFL1, and GRS. Bfl-1 protein suppresses apoptosis induced by the p53 tumor suppressor protein in a manner similar to other Bcl-2 family members such as Bcl-2, Bcl-xL and EBV-BHRF1. In addition, the bfl-I gene cooperates efficiently with the Ela oncogene in transformation of primary rodent epithelial cells. The human bfl-1 gene may play an important role in carcinogenesis.
Synonyms
Bcl-2-related protein A1; Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS; BCL2A1; BCL2L5, BFL1, GRS, HBPA1
Gene Name
BCL2A1
Gene ID
597
UniProt
Q16548
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Bcl2A1.
Clonality
Polyclonal
Tissue Specificity
Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.
Applications
Flow Cytometry
Field of Research
Apoptosis, Cell Biology, Intracellular
Purification
Immunogen affinity purified.
Form
Liquid
Function
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity) . Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity) . .
References & Citations
1. Choi, S. S., Park, S. H., Kim, U.-J., Shin, H.-S. Bfl-1, a Bcl-2-related gene, is the human homolog of the murine A1, and maps to chromosome 15q24.3. Mammalian Genome 8: 781-782, 1997. 2. D'Sa-Eipper, C., Subramanian, T., Chinnadurai, G. Bfl-1, a bcl-2 homologue, suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity. Cancer Res. 56: 3879-3882, 1996.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
20132 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Bcl-2-related protein A1
Subcellular Location
Cytoplasm.
Sequence Similarities
Contains 5 BAG domains.
Protein Name
Bcl-2-related protein A1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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