Anti-Bag5 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene. The protein encoded by this gene is a member of the BAG1-related protein family. Bag5 is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death and thus promotes neurodegeneration.
Synonyms
BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5; BAG5; KIAA0873
Gene Name
BAG5
Gene ID
9529
UniProt
Q9UL15
Host
Rabbit
Reactivity
Rat, Mouse, Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human BAG5, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Clonality
Polyclonal
Tissue Specificity
Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. .
Applications
Flow Cytometry
Field of Research
Apoptosis, Apoptotic Markers, Cancer, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .
References & Citations
1. Takayama S, Xie Z, Reed JC (Feb 1999) . An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem 274 (2) : 781–6. 2 Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (Dec 2004) . BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 44 (6) : 931–45. 3 Entrez Gene: BAG5 BCL2-associated athanogene 5.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
51200 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
BAG family molecular chaperone regulator 5
Subcellular Location
Cytoplasm .
Sequence Similarities
Contains 5 BAG domains.
Protein Name
BAG family molecular chaperone regulator 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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