Anti-Aquaporin 9/AQP9 Antibody Picoband® Fluoro488 Conjugated
Selected Variant
PA2094-Fluoro488
Size: 100 µg/Vial
Product Specifications
Background
Aquaporin-9 is a protein that in humans is encoded by the AQP9 gene. AQP9 encodes a 295-amino-acid protein with the amino acid sequence identity with AQP3 (48%), AQP7 (45%), and other aquaporins (approximately 30%), suggesting that AQP3, AQP7, and AQP9 belong to a subfamily of the aquaporin family. AQP9 is the major glycerol channel in mouse erythrocytes and suggest that this transport pathway may contribute to the virulence of intraerythrocytic stages of malarial infection.
Synonyms
Aquaporin-9; AQP-9; Aquaglyceroporin-9; Aqp9
Gene Name
AQP9
Gene ID
64008
UniProt
Q9JJJ3
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Aquaporin 9.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cancer, Channels, Metabolism, Plasma Membrane, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na (+), K (+), Cl (-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol (By similarity) . .
References & Citations
1. Entrez Gene: AQP9 aquaporin 9 2. Ishibashi, K., Kuwahara, M., Gu, Y., Tanaka, Y., Marumo, F., Sasaki, S. Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. Biochem. Biophys. Res. Commun. 244: 268-274, 1998. 3. Liu, Y., Promeneur, D., Rojek, A., Kumar, N., Frokiaer, J., Nielsen, S., King, L. S., Agre, P., Carbrey, J. M. Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. Proc. Nat. Acad. Sci. 104: 12560-12564, 2007.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
31764 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Aquaporin-9
Subcellular Location
Membrane ; Multi-pass membrane protein .
Protein Name
Aquaporin-9
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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