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Anti-PMP70/ABCD3 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The gene was assigned to human chromosome 1p21-p22 by in situ hybridization. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders.

Synonyms

ATP-binding cassette sub-family D member 3;70 kDa peroxisomal membrane protein; PMP70; ABCD3; PMP70, PXMP1

Gene Name

ABCD3

Gene ID

5825

UniProt

P28288

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human PMP70, different from the related mouse and rat sequences by one amino acid.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Alzheimer's Disease, Cancer, Lipid Metabolism, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Organelle Proteins, Organelles, Protein Trafficking, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382) . The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity (PubMed:11248239) . .

References & Citations

1. Gartner J, Moser H, Valle D (June 1993) . Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome.Nat Genet 1 (1) : 16–23. 2. Gartner J, Kearns W, Rosenberg C, Pearson P, Copeland NG, Gilbert DJ, Jenkins NA, Valle D (April 1993) . Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3. Genomics 15 (2) : 412–4. 3. Entrez Gene: ABCD3 ATP-binding cassette, sub-family D (ALD), member 3.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

75 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

ATP-binding cassette sub-family D member 3

Subcellular Location

Peroxisome membrane ; Multi-pass membrane protein .

Sequence Similarities

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein Name

ATP-binding cassette sub-family D member 3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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