Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ABCB4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Adenosine triphosphate-binding cassette subfamily B, member 4 (ABCB4), also called MDR3, is a protein that in humans is encoded by the ABCB4 gene. MDR1 and MDR3 constitute the human P-glycoprotein gene family. The MDR3 gene contains 28 exons and 27 of these contain coding sequences for the two homologous halves of the protein that correlate with functional domains. MDR3 gene mutations represent a genetic factor involved in this peculiar form of cholesterol gallstone disease in adults.

Synonyms

Multidrug resistance protein 3;3.6.3.44; ATP-binding cassette sub-family B member 4; P-glycoprotein 3; ABCB4; MDR3, PGY3

Gene Name

ABCB4

Gene ID

5244

UniProt

P21439

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human ABCB4.

Clonality

Polyclonal

Tissue Specificity

Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.

Applications

Flow Cytometry

Field of Research

ATPases, Cancer, Lipid Metabolism, Metabolism, Nuclear Import/Export, Plasma Membrane, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.

References & Citations

1. Lincke, C. R., Smit, J. J., van der Velde Koerts, T., Borst, P. Structure of the human MDR3 gene and physical mapping of the human MDR locus. J. Biol. Chem. 266: 5303-5310, 1991. 2. Rosmorduc, O., Hermelin, B., Poupon, R. MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. Gastroenterology 120: 1459-1467, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

141523 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Multidrug resistance protein 3

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Protein Name

Phosphatidylcholine translocator ABCB4

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Mouse CD40 ELISA Kit
MBS824722-01 96 Tests

Mouse CD40 ELISA Kit

Ask
View Details
Mouse CD40 ELISA Kit
MBS824722-02 5x 96 Tests

Mouse CD40 ELISA Kit

Ask
View Details
Frozen Tissue Sections, Lung
CS525524 5x 5 µm

Frozen Tissue Sections, Lung

Ask
View Details
Hsa-miR-548az-3p agomir
HY-R01670A-01 5 nmol

Hsa-miR-548az-3p agomir

Ask
View Details
Hsa-miR-548az-3p agomir
HY-R01670A-02 20 nmol

Hsa-miR-548az-3p agomir

Ask
View Details
Glucose Oxidase Activity Fluorometric Microplate Assay Kit
MBS8327510-01 100 Assays

Glucose Oxidase Activity Fluorometric Microplate Assay Kit

Ask
View Details