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Anti-Bonzo/CXCR6 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

CXCR6 (Chemokine, CXC Motif, Receptor 6), also known as STRL33, is a protein that in humans is encoded by the CXCR6 gene. By Southern blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al. (1997) mapped the single-copy STRL33 gene to chromosome 3. Matloubian et al. (2000) found that human and mouse cells expressing CXCR6 showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. Kim et al. (2001) concluded that CXCR6 may be important in the trafficking of effector T cells mediating type-1 inflammation.

Synonyms

C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD186; CXCR6; BONZO, STRL33, TYMSTR

Gene Name

CXCR6

Gene ID

10663

UniProt

O00574

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Bonzo, different from the related mouse and rat sequences by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Expressed in lymphoid tissues and activated T cells.

Applications

Flow Cytometry

Field of Research

Antiviral Signaling, Host-Virus Interaction, Immune System Diseases, Immunology, Interspecies Interaction, Microbiology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

References & Citations

1. Kim, C. H., Kunkel, E. J., Boisvert, J., Johnston, B., Campbell, J. J., Genovese, M. C., Greenberg, H. B., Butcher, E. C. Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J. Clin. Invest. 107: 595-601, 2001. 2. Liao, F., Alkhatib, G., Peden, K. W. C., Sharma, G., Berger, E. A., Farber, J. M. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185: 2015-2023, 1997. 3. Matloubian, M., David, A., Engel, S., Ryan, J. E., Cyster, J. G. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nature Immun. 1: 298-304, 2000.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

39280 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

C-X-C chemokine receptor type 6

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Protein Name

C-X-C chemokine receptor type 6

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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