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Anti-ALDH3A1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

ALDH3A1 (Aldehyde Dehydrogenase, Family 3, Subfamily A, Member 1), also known as ALDH3, is an enzyme that in humans is encoded by the ALDH3A1 gene. By in situ hybridization, Hiraoka et al. (1995) mapped the ALDH3 gene to 17p11.2. ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.

Synonyms

Aldehyde dehydrogenase, dimeric NADP-preferring;1.2.1.5; ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1; ALDH3A1; ALDH3

Gene Name

ALDH3A1

Gene ID

218

UniProt

P30838

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human ALDH3A1.

Clonality

Polyclonal

Tissue Specificity

High levels in stomach, esophagus and lung; low level in the liver and kidney.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Neuroscience, Oxidative Stress, Pathways and Processes, Redox Metabolism, Sensory System, Signal Transduction, Visual System

Purification

Immunogen affinity purified.

Form

Liquid

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.

References & Citations

1. Hiraoka, L. R., Hsu, L., Hsieh, C.-L. Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13. Genomics 25: 323-325, 1995. 2. Santisteban, I., Povey, S., West, L. F., Parrington, J. M., Hopkinson, D. A. Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3. Ann. Hum. Genet. 49: 87-100, 1985.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50395 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Aldehyde dehydrogenase, dimeric NADP-preferring

Subcellular Location

Cytoplasm.

Sequence Similarities

Belongs to the aldehyde dehydrogenase family.

Protein Name

Aldehyde dehydrogenase, dimeric NADP-preferring

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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