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Anti-Factor VIII/F8 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Coagulation Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF) . By in situ hybridization, Tantravahi et al. (1986) concluded that the F8 gene is located in the proximal part of chromosome Xq28 with probes DX13 and St14 distally located. The F8 gene encodes coagulation factor VIII, a large plasma glycoprotein that functions in the blood coagulation cascade as a cofactor for the factor IXa-dependent activation of factor X (F10) . Factor VIII is activated proteolytically by a variety of coagulation enzymes, including thrombin (F2) . Factor VIII is tightly associated in the blood with von Willebrand factor (VWF), which serves as a protective carrier protein for factor VIII (Toole et al., 1984; Hoyer, 1994) .

Synonyms

Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain; F8; F8C

Gene Name

F8

Gene ID

2157

UniProt

P00451

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Factor VIII.

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Angiogenesis, Cancer, Cardiovascular, Invasion/Microenvironment, Platelets, Serum Proteins, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.

References & Citations

1. Hoyer, L. W. Hemophilia A. New Eng. J. Med. 330: 38-45, 1994. 2. Tantravahi, U., Murty, V. V. V. S., Jhanwar, S. C., Toole, J. J., Woozney, J. M., Chaganti, R. S. K., Latt, S. A. Physical mapping of the factor VIII gene proximal to two polymorphic DNA probes in human chromosome band Xq28: implications for factor VIII gene segregation analysis. Cytogenet. Cell Genet. 42: 75-79, 1986. 3. Toole, J. J., Knopf, J. L., Wozney, J. M., Sultzman, L. A., Buecker, J. L., Pittman, D. D., Kaufman, R. J., Brown, E., Shoemaker, C., Orr, E. C., Amphlett, G. W., Foster, W. B., Coe, M. L., Knutson, G. J., Fass, D. N., Hewick, R. M. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature 312: 342-347, 1984.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

267009 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Coagulation factor VIII

Subcellular Location

Secreted, extracellular space.

Sequence Similarities

Belongs to the multicopper oxidase family.

Protein Name

Coagulation factor VIII

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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